Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 37 Reviews
8.9
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Selenium (from SelenoExcell® High Selenium Yeast) (Saccharomyces cerevisiae)
50 mcg
90%
Molybdenum (from molybdenum glycinate chelate)
50 mcg
110%
N-Acetylcysteine (NAC)
600 mg
†
Top Medical Research Studies
9.5
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
Read More
9.5
Selenium nanoparticles combat bacterial infections
We explored how selenium nanoparticles (SeNPs) can tackle bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). By modifying the surface chemistry of SeNPs using different surfactants, we could influence their effectiveness in fighting bacteria and modulating immune responses.
Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.
In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.
In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Read More
9
Selenium nanoparticles combat bacteria
We explored the potential of selenium nanoparticles (SeNPs) as a treatment option for Pseudomonas aeruginosa, a notorious bacteria known for its antibiotic resistance and ability to form biofilms. The study examined how effectively these SeNPs can target bacterial infections, particularly focusing on their antibacterial and anti-biofilm properties.
SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.
Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.
Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.
Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.
Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
Read More
Most Useful Reviews
9.5
Reduces bacterial symptoms
Great ACC Long helps remove sputum during colds. It's more affordable than pharmacy prices, and with 600 mg per capsule, one daily suffices. Acetylcysteine, a derivative of the amino acid cysteine, has a mucolytic effect, aiding sputum discharge and breaking disulfide bonds in mucoproteins. Its antioxidant properties neutralise harmful oxidising radicals, protecting against free radical damage typical in inflammatory reactions. This is particularly beneficial for acute respiratory infections with a high fever. It also reduces bacterial exacerbations in chronic conditions like bronchitis and cystic fibrosis.
Read More
9.5
Improves lung recovery
After contracting COVID in January, I took NAC daily alongside other medications. My lung damage was minor, and studies indicate that NAC can significantly control moderate COVID-associated pneumonia, improving blood oxygen levels and reducing hospital stays for those on NAC. I continue to take it for its benefits, including lowering homocysteine, which helps prevent blood clots and vascular damage. NAC is also effective against paracetamol overdoses.
Read More
9.5
Disrupts bacterial biofilm
Studies show that over 80% of human bacterial infections relate to biofilm, and simple antibiotics often fail. Removing biofilm is vital for effective treatment. N-acetylcysteine (NAC) has shown efficacy in inhibiting biofilm formation and enhancing the effectiveness of antibiotics. It increases glutathione levels to flush toxins and protect the kidneys while supporting the respiratory system.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
- All Researches
9.5
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.
Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
Read More
9.5
Selenium nanoparticles combat bacterial infections
We explored how selenium nanoparticles (SeNPs) can tackle bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). By modifying the surface chemistry of SeNPs using different surfactants, we could influence their effectiveness in fighting bacteria and modulating immune responses.
Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.
In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.
In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Read More
9.5
We delved into how selenium nanoparticles (SeNPs) can raise our body's defenses against bacterial infections, specifically Mycobacterium bovis, which causes tuberculosis. The study focused on combining SeNPs with an antigen called AH (Ag85A-HspX) to see if this partnership could improve respiratory mucosal immunity and enhance protection against this serious illness.
In our exploration, we synthesized SeNPs and administered them intranasally in mice, alongside the AH antigen. The results were quite enlightening. SeNPs proved to be more effective than polyinosinic-polycytidylic acid (Poly IC) in stimulating dendritic cells, which play a crucial role in activating our immune response. This activation led to a significant increase in tissue-resident memory T cells and effector CD4 T cells in the lungs, strengthening the overall immune response to the infection.
Moreover, mice that received the combination of AH and SeNPs demonstrated impressive outcomes. There was a notable increase in specific antibody levels in the respiratory system, along with a boost in immune markers associated with fighting infections. Not only did these mice show enhanced mucosal immunity, but they also had lower infection loads and reduced inflammatory damage in their lungs after being challenged with M. bovis. Overall, this study highlights the potential of selenium nanoparticles as innovative adjuvants in vaccines, paving the way for future clinical investigations in both cattle and possibly humans.
In our exploration, we synthesized SeNPs and administered them intranasally in mice, alongside the AH antigen. The results were quite enlightening. SeNPs proved to be more effective than polyinosinic-polycytidylic acid (Poly IC) in stimulating dendritic cells, which play a crucial role in activating our immune response. This activation led to a significant increase in tissue-resident memory T cells and effector CD4 T cells in the lungs, strengthening the overall immune response to the infection.
Moreover, mice that received the combination of AH and SeNPs demonstrated impressive outcomes. There was a notable increase in specific antibody levels in the respiratory system, along with a boost in immune markers associated with fighting infections. Not only did these mice show enhanced mucosal immunity, but they also had lower infection loads and reduced inflammatory damage in their lungs after being challenged with M. bovis. Overall, this study highlights the potential of selenium nanoparticles as innovative adjuvants in vaccines, paving the way for future clinical investigations in both cattle and possibly humans.
Read More
9.5
We explored how selenium-tellurium doped copper oxide nanoparticles (SeTe-CuO NPs) can effectively tackle bacterial infections and improve wound healing. This innovative study focused on the nanoparticles’ dual photodynamic and photothermal properties, which become activated under near-infrared (NIR) light.
In our findings, these nanoparticles demonstrated a remarkable ability to eradicate up to 99% of bacteria and showed significant inhibition of biofilm formation. This is crucial, as biofilms can make infections harder to treat. The in vitro tests established that these NPs effectively combat bacterial infections, leading us to believe they have practical applications for improving wound recovery.
We also observed that, when implemented in vivo, the SeTe-CuO NPs significantly accelerated the closure of wounds. They helped clear bacteria quickly from wounds, offering a promising solution for those struggling with infections. Overall, the study highlights a powerful new tool in the fight against multidrug-resistant bacteria, demonstrating its potential in advancing therapeutic interventions in wound management.
In our findings, these nanoparticles demonstrated a remarkable ability to eradicate up to 99% of bacteria and showed significant inhibition of biofilm formation. This is crucial, as biofilms can make infections harder to treat. The in vitro tests established that these NPs effectively combat bacterial infections, leading us to believe they have practical applications for improving wound recovery.
We also observed that, when implemented in vivo, the SeTe-CuO NPs significantly accelerated the closure of wounds. They helped clear bacteria quickly from wounds, offering a promising solution for those struggling with infections. Overall, the study highlights a powerful new tool in the fight against multidrug-resistant bacteria, demonstrating its potential in advancing therapeutic interventions in wound management.
Read More
9
We explored how combining selenium-tellurium nanoparticles with zinc oxide can help tackle bacterial infections, especially those stubborn biofilms. The goal was to create a hybrid nanoparticle that could leverage both photodynamic and photothermal properties to effectively disrupt bacterial growth.
In our synthesis of these SeTe-ZnO nanoparticles, we observed a significant impact on both Gram-positive and Gram-negative bacteria. Not only did these nanoparticles show efficacy in combating various bacterial strains, they also played a role in disrupting biofilm formation, which is often a major barrier to treatment success.
Furthermore, studies indicated that the SeTe-ZnO nanoparticles are biocompatible, which means they are safe to use in biological contexts, such as wound healing. Their impressive wound healing abilities suggest they could be a versatile option in both preventing and treating infections, demonstrating promising potential in the field of antimicrobial therapy.
In our synthesis of these SeTe-ZnO nanoparticles, we observed a significant impact on both Gram-positive and Gram-negative bacteria. Not only did these nanoparticles show efficacy in combating various bacterial strains, they also played a role in disrupting biofilm formation, which is often a major barrier to treatment success.
Furthermore, studies indicated that the SeTe-ZnO nanoparticles are biocompatible, which means they are safe to use in biological contexts, such as wound healing. Their impressive wound healing abilities suggest they could be a versatile option in both preventing and treating infections, demonstrating promising potential in the field of antimicrobial therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 37 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduces bacterial symptoms
Great ACC Long helps remove sputum during colds. It's more affordable than pharmacy prices, and with 600 mg per capsule, one daily suffices. Acetylcysteine, a derivative of the amino acid cysteine, has a mucolytic effect, aiding sputum discharge and breaking disulfide bonds in mucoproteins. Its antioxidant properties neutralise harmful oxidising radicals, protecting against free radical damage typical in inflammatory reactions. This is particularly beneficial for acute respiratory infections with a high fever. It also reduces bacterial exacerbations in chronic conditions like bronchitis and cystic fibrosis.
Read More
9.5
Improves lung recovery
After contracting COVID in January, I took NAC daily alongside other medications. My lung damage was minor, and studies indicate that NAC can significantly control moderate COVID-associated pneumonia, improving blood oxygen levels and reducing hospital stays for those on NAC. I continue to take it for its benefits, including lowering homocysteine, which helps prevent blood clots and vascular damage. NAC is also effective against paracetamol overdoses.
Read More
9.5
Disrupts bacterial biofilm
Studies show that over 80% of human bacterial infections relate to biofilm, and simple antibiotics often fail. Removing biofilm is vital for effective treatment. N-acetylcysteine (NAC) has shown efficacy in inhibiting biofilm formation and enhancing the effectiveness of antibiotics. It increases glutathione levels to flush toxins and protect the kidneys while supporting the respiratory system.
Read More
9.5
Prevents lung infection
Irreplaceable. With a viral infection, it prevents progression to the lungs. It performed well, and the cough disappears before it begins.
Read More
8.8
Prevents throat infections
This product is fantastic. I take two capsules daily and haven't experienced a throat infection since I started NAC.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Iwata H, Ikeda A, Itoh M, Ketema RM, Tamura N, et al. Association between prenatal exposure to maternal metal and trace elements and Streptococcus infection: A prospective birth cohort in the Japan Environment and Children's Study. PLoS One. 2025;20:e0319356. doi:10.1371/journal.pone.0319356
- Wang Y, Khan SS, Ullah I, Rady A, Aldahmash B, et al. One pot synthesis of SeTe-ZnO nanoparticles for antibacterial and wound healing applications. RSC Adv. 2025;15:3439. doi:10.1039/d4ra06594h
- Perfileva AI, Zakharova OV, Graskova IA, Krutovsky KV. Effect of Selenium, Copper and Manganese Nanocomposites in Arabinogalactan Matrix on Potato Colonization by Phytopathogens and . Plants (Basel). 2024;13. doi:10.3390/plants13243496
- Dong J, Wang Z, Fei F, Jiang Y, Jiang Y, et al. Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways. Vet Sci. 2024;11. doi:10.3390/vetsci11120674
- Thamayandhi C, El-Tayeb MA, Syed SR, Sivaramakrishnan R, Gunasekar B. Antibacterial and anti-biofilm efficacy of selenium nanoparticles against Pseudomonas aeruginosa: Characterization and in vitro analysis. Microb Pathog. 2024;196:106998. doi:10.1016/j.micpath.2024.106998
- Tran P, Abidi N, Bergfeld N, Shashtri M, Reid TW. Selenium Bandages and Cotton Cloth That Kill Microorganisms in Wounds. Mil Med. 2024;189:179. doi:10.1093/milmed/usae069
- Wang Y, Feng L, Jiang WD, Wu P, Liu Y, et al. The effect of selenium on the intestinal health of juvenile grass carp based on the ERS-autophagy pathway. Fish Shellfish Immunol. 2024;153:109808. doi:10.1016/j.fsi.2024.109808
- Canbaz FA, Yurtçu M, Oltulu P, Taştekin G, Kocabaş R, et al. Investigation of the Effects of N-acetylcysteine and Selenium on Vesicoureteral Reflux Nephropathy: An Experimental Study. J Pediatr Surg. 2024;59:161616. doi:10.1016/j.jpedsurg.2024.06.024
- Gamal AA, Hussein MAM, Sayed HAE, El-Sayed EM, Youssef AM, et al. Hybrid nanoparticles combining nanoselenium-mediated Carica papaya extract and trimethyl chitosan for combating clinical multidrug-resistant bacteria. Int J Biol Macromol. 2024;277:134359. doi:10.1016/j.ijbiomac.2024.134359
- Joshi P, Soares JM, Martins GM, Zucolotto Cocca LH, De Boni L, et al. Enhancing the efficacy of antimicrobial photodynamic therapy through curcumin modifications. Photochem Photobiol. 2025;101:359. doi:10.1111/php.14000
- Gokhale KM, Patravale V, Pingale R, Pandey P, Vavilala SL. Se-functionalized ZIF-8 nanoparticles: synthesis, characterization and disruption of biofilms and quorum sensing in. Biomed Mater. 2024;19. doi:10.1088/1748-605X/ad6549
- Bian Y, Zhao K, Hu T, Tan C, Liang R, et al. A Se Nanoparticle/MgFe-LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction. Adv Sci (Weinh). 2024;11:e2403791. doi:10.1002/advs.202403791
- Bu Q, Jiang D, Yu Y, Deng Y, Chen T, et al. Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection. Drug Resist Updat. 2024;76:101102. doi:10.1016/j.drup.2024.101102
- Ge X, Liang Z, Li K, Dong Y, Wang Y, et al. Selenium nanoparticles enhance mucosal immunity against Mycobacterium bovis infection. Int Immunopharmacol. 2024;137:112384. doi:10.1016/j.intimp.2024.112384
- Yang F, Shu R, Dai W, Li B, Liu C, et al. HSe-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence. Biomaterials. 2024;311:122659. doi:10.1016/j.biomaterials.2024.122659
- Ullah I, Khan SS, Ahmad W, Liu L, Rady A, et al. NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing. Commun Chem. 2024;7:131. doi:10.1038/s42004-024-01215-1
